Has anyone replaced the wheel bearing hubs on a 2000 Bonneville?

no, but i probably will be doing one this weekend...

just so you know its the same as doing it on the older bonnies

Yes I have a few times now, it can be done in your driveway with simple hand tools.
The toughest bolt is top dead center (only 3 total) but if you turn the wheel and use a universal socket adapter you will be fine.
Think I posted some stuff once before too, try a search.

Yes, there are several members here that have had to replace front hub assemblies including myself. I had my local garage do my work. Maybe some of the other veterans will chime in soon. Are you planning to do them yourself?

Any idea on how many miles before the hubs are giving out?

Both front were gone on mine at 80k, drivers side failed @60k.
Changed the drivers side again last year at 120k.

Mine'* at 130k miles now, and the driver'* side is giving out.

Whether or not this is the second time, I'll have to ask Drifter or Tamara.

mine is at 88 and needs one pretty badly...
i strted to notice a little play around 65-70k

Thank you everyone!