Mike...Vortec is also a brand/kit of supercharger. They make a kit that would bolt right onto my 5.3L Silverado.
The stock gaskets etc are rated for 10psi. Many people have easily and continually pushed 13-15 psi without a problem. I know adapters have been made out of intercoolers for the MP112 and other chargers, don't think I've ever seen a Vortec adapted. But as long as things are relatively the same as some of the other chargers....it should be possible.
One issue you will run into is supporting mods. Our front exhaust manifold, heads and cam are all restrictive on the motor. While having the boost number is nice..it'* not much more than excess pressure stacked in the intake manifold. To be useful, it needs to be flowing through the heads and out the exhaust pipes.
00 Regal GS: All kinds of cool stuff.