Actually I have a Powertuner and an AFC 2.0 (very similar to 2.2)
I run both for a couple reasons, but the biggest is the fact that I dont have to re-prog the PCM daily as temps/weather/ect change. I can just scan the car and adjust accordingly keeping me running awesome no matter what the weather is.
Also if I'm on a long road trip I just lower the settings via AFC and save some gas
On the flip side if the AFC makes your shifts "mushy" due to the fact that its lying to the PCM. I dont have this issue however as my press. sensor is locked
My counterpart at HumPerformance ran one for while and ran about .15 faster, but he has swapped car and will see more from it than the rrst of us. He sold it because of the softer shifting.