"You're not my type"
"Did you just wake up? I mean, it'* 8 o'clock, and you're at a club."
"I don't like guys with Dark hair"
"I have to go to the bathroom"
"Do you always look like that?"
"I like Harry Potter too, but you're no wizard."
"You're not like other guys I've met... they're usually attractive and intellegent"
At least, I think they were trying to pick me up.... :o
I don't know about the best pick up line, but I think I have the most successful. I'm 41 with a 18 and a 19 year old son. My wife asks me if i want to visit Vegas 30 months ago... I now have a 21 month old son. I'd say that'* a great pick-up line.